游戏厅捕鱼

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                            西格列他钠

                            西格列他钠(商品名:双洛平® /Bilessglu®)

                            ZHENDUI2XINGTANGNIAOBINGHUANZHEZHILIAOXUQIU,WEIXINSHENGWUZIZHUSHEJI、HECHENG、SHAIXUANHEKAIFALEXINYIDAIYIDAOSUZENGMINJILEIHOUXUANYAOWU——XIGELIETANA(Chiglitazar),TASHUYUHUAXUEJIEGOUWANQUANBUTONGYUSAIZUOWANERTONGLEI(Thiazolidinedione, TZD)DEGOUXIANGXIANZHIXINGGUOYANGHUAWUMEIZENGZHITIJIHUOSHOUTIQUANJIDONGJI(Configuration-restricted PPAR pan agonist),NENGGOUTONGSHIDIQIANGDUDEJIHUOPPARα、γHEδSHOUTI,GENGYOUXIAODIYIZHIYOUFEIPANGJIYANZHENGYINZIJIHUODECDK5DUIPPARγDELINSUANHUA,CONGERXUANZEXINGDIGAIBIANYIXILIEYUYIDAOSUZENGMINXIANGGUANJIYINDEBIAODA。YINCIZAI2XINGTANGNIAOBINGZHILIAOZHONG,BUDANKEYIKONGZHIXUETANG,HAIKEYIZHILIAOHUANZHETONGCHANGBANFADEZHIDAIXIEJINENGLIANGDAIXIEWENLUAN,JINERYOUYIYUXINXUEGUANBINGFAZHENGDEYUFANGHEKONGZHI,CHENGWEIYIGEXINXINGQIEGENGWEIZONGHEDE2XINGTANGNIAOBINGQIANZAIYAOWUZHILIAOSHOUDUAN。

                            已完成的临床前研究和临床I、II期试验结果中,西格列他钠都表现出与现有TZD类药物不同的体外活性和体内疗效特点,并表现出良好的综合治疗效果及临床安全性特征。目前,已经完成单药治疗2型糖尿病的两个大型临床III游戏厅捕鱼期试验,正在进行试验数据分析。


                            西格列他钠通过不同亚型对靶器官实现胰岛素增敏及重新平衡糖、脂及能量代谢调节的分子机制图

                            西格列他钠调节PPARγ介导的转录活性的分子作用机制



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